Analysis of safety data indicates differences among these agents in drug interactions and use in pregnancy. Analysis of safety data reveals pharmacokinetic drug interactions for erythromycin and clarithromycin with theophylline, terfenadine, and carbamazepine that are not found with azithromycin. Both erythromycin and azithromycin are pregnancy category B drugs; clarithromycin is a category C drug.
The numerous differences in pharmacokinetics, microbiology, safety, and costs among erythromycin, clarithromycin, and azithromycin can be used in the judicious selection of treatment for indicated infections. The higher the score, the more severe patient's symptoms. Development and validation of a patient-assessed gastroparesis symptoms severity measure: the Gastroparesis Cardinal Symptom Index.
Ailment Pharm Ther ; Nepean Dyspepsia Index NDI is a measure of symptom status and quality of life in functional dyspepsia. Total score range would be For the NDI, a lower number is better meaning the symptom is not effecting quality of life and a higher score closer to 50 is worse meaning it is effecting patients quality of life. Quality of life in functional dyspepsia: responsiveness of the Nepean Dyspepsia Index and developement of a new iten short form. Aliment Pharmacol Ther This is a Validated instrument for measuring symptom severity in patients with gastroparesis.
This scoring is based on a Likert Scale from with zero being no symptom and five being very severe symptoms on 9 subscales, making the overall score range from The higher the score, the more severe patient's symptoms are. The scale is reported in the references. The change was calculated by measuring the end of treatment minus baseline GCSI score. This is a calculation taken with GCSI score at end of treatment minus baseline. Negative value reflects this change.
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Warning You have reached the maximum number of saved studies Comparison of Two Macrolides, Azithromycin and Erythromycin, for Symptomatic Treatment of Gastroparesis AZI The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.
Federal Government. Read our disclaimer for details. First Posted : March 25, Results First Posted : December 5, Last Update Posted : December 5, Study Description. Detailed Description:. Resource links provided by the National Library of Medicine Drug Information available for: Erythromycin Erythromycin stearate Erythromycin ethylsuccinate Erythromycin phosphate Azithromycin Azithromycin dihydrate Azithromycin monohydrate. FDA Resources. Arms and Interventions. The dose of Azithromycin was determined based on our dose response curve obtained on 10 healthy subjects who were given three different doses of Azithromycin, 50 mg, mg and mg and underwent breath testing to determine the gastric emptying half-time.
It is available as a pill or injection. The antibiotic Zithromax azithromycin is derived from erythromycin, another type of antibiotic. Although both macrolides, a class of antibiotics with large molecular size technically Zithromax is an azalide, and erythromycin is a macrolide.
In chemical terms, Zithromax shares the exact same lactose-macrolide structure as erythromycin save for the injection of methylated nitrogen in the lactone ring. This small difference tweaks the bacterial coverage of Zithromax and curiously changes its route of metabolism. Whereas erythromycin is metabolized by the cytochrome P system, Zithromax isn't. Thus, Zithromax interacts with fewer drugs, unlike erythromycin, which has a drug-drug interaction with some statins e. Like the other macrolides—erythromycin and clarithromycin—Zithromax works by binding to the bacteria 50S ribosomal subunit, thus interfering with the bacteria's ability to produce proteins.
Bacteria need to produce proteins to survive. Depending on the organism and the drug concentration, macrolides can be either bacteriostatic [stopping bacterial growth] or bactericidal [killing bacteria]. It should be noted that high levels of antibiotic resistance make Zithromax a poor choice for treating certain infections like community-acquired pneumonia, otitis media ear infection , and acute sinusitis. Of particular note, Zithromax is ineffective in combating infections caused by MRSA, a superbug with broad antibacterial resistance.
Depending on the route of administration, Zithromax is available in tablets, oral suspensions, injections, and ophthalmic solutions. Although unable to cross the blood-brain barrier and treat meningitis , Zithromax deeply pervades our tissue. This drug is also slowly released into systemic circulation and has a half-life of about 68 hours.
These amenable pharmacokinetic properties enable clinicians to administer the drug more infrequently. Half-life refers to the time it takes for the concentration of drug in the blood to decrease by half.
If the half-life is 48 hours, then 48 hours after administration, half the drug will have cleared from the blood. With respect to cervicitis and urethritis caused by infection with chlamydia, a single dose injection of Zithromax is equally effective as a seven-day course of doxycycline, therefore, limiting medication nonadherence.
The CDC recommends that clinicians treat gonorrhea and chlamydia together, so-called "dual" therapy. Therefore, a clinician typically prescribes a shot of the cephalosporin Rocephin to treat for possible gonorrhea, too. Please discuss such treatment with your physician. Although not as severe as erythromycin, azithromycin can also cause gastrointestinal distress like nausea or vomiting.
If you or a loved one has heart disease, it may be a good idea to avoid Zithromycin. Of note, QT-prolongation interferes with heart rhythms. The nice thing about Zithromycin is that its long half-life and fewer doses limit nonadherence. For example, one dose of this drug is a complete treatment; whereas, if you must take doxycycline on your own for a week, you may forget or stop.
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