Turchin also receives grants from pharmaceutical companies, but those grants did not fund this new research. One expert questioned whether his findings had much to do with statins at all. Redberg was not involved in Turchin's research. For example, those who take medications consistently might also eat better or exercise more, Redberg added. So a "small difference" between the groups "isn't that revealing," she said.
Redberg also noted that the study did not separate patients who had already had a heart attack or stroke. She said that there is plenty of good evidence to recommend statins to patients who have had cardiovascular problems, but that there is "little to no benefit" in using statins to prevent a cardiac event in those who haven't had one before.
The latter remains a topic of debate. Experts say that McDonagh's experience as a patient is uncommon, but exactly how uncommon is unclear. It is difficult to know whether a reported symptom is truly caused by statins, and many studies do not ask patients about common side effects, according to experts. Roughly one in five patients on statins experienced a side effect, the new study found.
This is higher than other studies have estimated, but it could have to do with the way the study was designed, Turchin said. Bad heart? Time to hit the gym. Nissen said that statins have developed a "bad reputation with the public," largely due to websites that peddle scary and unscientific claims about statins.
These claims, Nissen said, could actually increase reported side effects. The more patients are aware -- and perhaps fearful -- of statins and their side effects, the more likely they are to report those side effects.
This phenomenon is known as the "nocebo effect," the opposite of the placebo effect. Heavy media coverage of statins may also lead people to stop taking them, according to a study from the UK. However, this effect disappeared after six months.
New U. In rare cases, a doctor may suggest stopping statin treatment altogether and replacing it with a different cholesterol lowering drug. PCSK9 inhibitors bind to and inactivate the protein. This allows the liver to absorb more LDL cholesterol and reduce levels of this type of cholesterol in the blood.
Selective cholesterol absorption inhibitors SCAIs prevent the absorption of cholesterol in the small intestine. These drugs mainly reduce levels of LDL cholesterol.
Other treatment options include other lipid lowering therapies, which reduce levels of triglyceride fats in the blood. Studies suggest that high levels of triglycerides may increase the risk of stroke, although confirming this will require further research. There are many reasons that a person may want to come off statins.
Some people experience or are concerned about side effects. Others may feel that they no longer need to take this type of drug. Anyone who wants to stop taking a statin should talk to a doctor. In some cases, coming off these drugs can be dangerous.
The doctor may suggest reducing the dosage, combining the statin with another cholesterol lowering drug, or switching to another drug entirely. Eating a healthy diet is one way to keep cholesterol levels in check. Learn which foods to avoid and which to prioritize to maintain healthy…. Some cholesterol-lowering drugs work best when a person takes them in the evening, while others are equally effective in the morning. Learn more about….
Fasting before taking a cholesterol test used to be standard practice. Now, some doctors recommend that people do not fast before taking the test…. In this article, we look at a variety of lifestyle changes and natural supplements that help lower cholesterol levels and reduce the risk of heart….
Statins are drugs that can reduce levels of cholesterol in the blood. Learn about the types, their uses, and the risks of taking statins here. Everything you need to know about coming off statins. Medically reviewed by Dr. Payal Kohli, M. How statins work Why people come off statins Risks Safety Summary Statins are a class of drug that reduces levels of low-density lipoprotein LDL cholesterol in the blood. How statins work. Why people come off statins. Mayo Clinic does not endorse companies or products.
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This content does not have an English version. This content does not have an Arabic version. See more conditions. Statin side effects: Weigh the benefits and risks. Products and services. Statin side effects: Weigh the benefits and risks Statins are effective at lowering cholesterol and protecting against a heart attack and stroke, although they may lead to side effects for some people. By Mayo Clinic Staff. Thank you for Subscribing Our Housecall e-newsletter will keep you up-to-date on the latest health information.
Please try again. Something went wrong on our side, please try again. Show references Controlling cholesterol with statins. Food and Drug Administration. Accessed Jan. Rosenson RS. Statins: Actions, side effects and administration. Rosenson RS, et al.
Statin muscle-related adverse events. Ferri FF. Statin-induced muscle syndromes. In: Ferri's Clinical Advisor Philadelphia, Pa. Adhyaru BB, et al. Safety and efficacy of statin therapy. Nature Reviews Cardiology. Alonso R, et al. Diagnosis and management of statin intolerance. Journal of Atherosclerosis and Thrombosis. Mach F, et al. Adverse effects of statin therapy: Perception vs.
European Heart Journal. About cholesterol. American Heart Association. Statin intolerance. Rochester, Minn. Anyanwagu U, et al. Drug-induced diabetes mellitus: Evidence for statins and other drugs affecting glucose metabolism. Clinical Pharmacology and Therapeutics. Lopez-Jimenez F expert opinion.
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